中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值与突发性聋恢复的相关性。

Associations between neutrophil-to-lymphocyte/platelet-to-lymphocyte and recovery in sudden sensorineural hearing loss.

机构信息

Otolaryngology Department, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zheda Road, Hangzhou, 310027, China.

Otolaryngology Department, Jinhua TCM Hospital, Shuangxi Road, Jinhua, 321000, China.

出版信息

Biomark Med. 2024 Feb;18(3):115-122. doi: 10.2217/bmm-2022-0729. Epub 2024 Mar 4.

DOI:10.2217/bmm-2022-0729

PMID:38436264

Abstract

This study investigated the nonlinear associations between neutrophil-to-lymphocyte (NLR)/platelet-to-lymphocyte (PLR) and recovery rates in sudden sensorineural hearing loss (SSNHL). Total of 244 SSNHL patients were included. The primary outcome was recovery rate. A nonlinear association was detected between NLR and recovery rate using the LOWESS method, with a knot of 3. Patients with NLR ≥3 had a higher recovery rate than NLR <3. Using the linear-spline function, NLR was significantly associated with high recovery rate when NLR was <3. However, when NLR was ≥3, this association became nonsignificant. The trend test showed a similar result. PLR was not associated with recovery rate. The association between NLR and recovery rate is nonlinear, with a knot of around three. PLR is not associated with recovery rate.

摘要

本研究探讨了中性粒细胞与淋巴细胞比值（NLR）/血小板与淋巴细胞比值（PLR）与突发性聋（SSNHL）恢复率之间的非线性关系。共纳入 244 例 SSNHL 患者。主要结局为恢复率。使用 LOWESS 法检测到 NLR 与恢复率之间存在非线性关系，结点为 3。NLR≥3 的患者恢复率高于 NLR<3 的患者。使用线性样条函数，当 NLR<3 时，NLR 与高恢复率显著相关。然而，当 NLR≥3 时，这种相关性变得不显著。趋势检验也得到了类似的结果。PLR 与恢复率无关。NLR 与恢复率之间的关系是非线性的，结点约为 3。PLR 与恢复率无关。