Zhongguo Dang Dai Er Ke Za Zhi. 2024 Feb 15;26(2):107-117. doi: 10.7499/j.issn.1008-8830.2309059.
Meropenem is one of the most widely used special-grade antimicrobial agents in the treatment of neonatal sepsis. However, its irrational use has led to an increasingly severe problem of bacterial multidrug resistance. The guideline was developed following standardized methods and procedures, and provides 12 recommendations specifically addressing 9 clinical issues. The recommendations cover various aspects of meropenem use in neonates, including timing of administration, recommended dosage, extended infusion, monitoring and assessment, antimicrobial adjustment strategies, treatment duration, and treatment strategies for carbapenem-resistant infections. The aim of the guideline is to provide evidence-based recommendations and guidance for the rational use of meropenem in neonates with sepsis.
美罗培南是治疗新生儿败血症最广泛使用的特殊级抗菌药物之一。然而，其不合理使用导致了日益严重的细菌多重耐药问题。本指南是按照标准化方法和程序制定的，提供了12项建议，具体针对9个临床问题。这些建议涵盖了美罗培南在新生儿使用的各个方面，包括给药时机、推荐剂量、延长输注时间、监测与评估、抗菌药物调整策略、治疗疗程以及耐碳青霉烯类感染的治疗策略。本指南的目的是为败血症新生儿合理使用美罗培南提供循证建议和指导。
