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灯盏花素治疗潜力的当前进展:最新综述

Current advances on the therapeutic potential of scutellarin: an updated review.

作者信息

Xie Yifei, Sun Guotong, Tao Yue, Zhang Wen, Yang Shiying, Zhang Li, Lu Yang, Du Guanhua

机构信息

Beijing City Key Laboratory of Drug Target and Screening Research, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, 100050, China.

Pharmaceutical College of Henan University, Kaifeng, 475004, China.

出版信息

Nat Prod Bioprospect. 2024 Mar 4;14(1):20. doi: 10.1007/s13659-024-00441-3.

Abstract

Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteraceae, and belongs to flavonoids. Scutellarin has a wide range of pharmacological activities, it is widely used in the treatment of cerebral infarction, angina pectoris, cerebral thrombosis, coronary heart disease, and other diseases. It is a natural product with great research and development prospects. In recent years, with in-depth research, researchers have found that wild scutellarin also has good therapeutic effects in anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, treatment of metabolic diseases, and protection of kidney. The cancer treatment involves glioma, breast cancer, lung cancer, renal cancer, colon cancer, and so on. In this paper, the sources, pharmacological effects, in vivo and in vitro models of scutellarin were summarized in recent years, and the current research status and future direction of scutellarin were analyzed.

摘要

野黄芩苷广泛分布于唇形科植物黄芩和菊科植物金盏花中,属于黄酮类化合物。野黄芩苷具有广泛的药理活性,被广泛用于治疗脑梗死、心绞痛、脑血栓形成、冠心病等疾病。它是一种具有巨大研发前景的天然产物。近年来,随着研究的深入,研究人员发现野黄芩苷在抗肿瘤、抗炎、抗氧化、抗病毒、治疗代谢性疾病和保护肾脏等方面也具有良好的治疗效果。其癌症治疗涉及胶质瘤、乳腺癌、肺癌、肾癌、结肠癌等。本文综述了近年来野黄芩苷的来源、药理作用、体内外模型,并分析了野黄芩苷的研究现状和未来方向。

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