Ozdemir Memis, Motmain Zekrullah, Ekinci Kubra, Saygılı Esranur
Department of Animal Science, Faculty of Agriculture, Ataturk University, Erzurum, Turkey.
Biochem Genet. 2025 Feb;63(1):1-21. doi: 10.1007/s10528-024-10706-8. Epub 2024 Mar 4.
The current meta-analysis was employed to combine the results of multiple studies into a single estimate related to B-LG, CSN3, DGAT1, PRL, GH, and PIT1 gene polymorphisms and their effects on milk production traits. The purpose of this meta-analysis was to investigate associations between B-LG, CSN3, DGAT1, GH, PIT1, and PRLgene polymorphisms with milk production traits in Holstein dairy cows. An extensive search was done from 2002 to 2022 year. Statistical analyses were performed by using Stata 11.2 software. Genetic models viz codominant (AA vs. AB, AA vs. BB, and AB vs. BB), dominant (AA + AB vs. BB), recessive (AA vs. AB + BB), and completely over-dominant (AA + BB vs. AB) were applied. The results of meta-analysis of association between B-LG genotypes with milk yield where found a significant (P < 0.05) and with fat and protein contents (P < 0.01). In CSN3 polymorphisms of A/A and A/B genotypes had a significant effect on fat yield (P < 0.05) and protein content (P < 0.01). DGAT1 polymorphisms had a significant effect on milk yield, fat yield, protein yield (P < 0.05), with fat and protein contents showed high effect (P < 0.01). No significant association was detected between GH and milk traits (P > 0.05). PIT1 genotype polymorphisms had a significant effect on milk yield (P < 0.05) and protein content (P < 0.01). PRL genotype polymorphisms were significantly associated with milk yield (P < 0.05), fat content and protein yield (P < 0.01). The B-LG, DGAT1,CSN3 and PRL gene polymorphisms could be utilized as good markers to improve milk production traits in the Holstein cattle breed.
当前的荟萃分析旨在将多项研究结果整合为一个与β-乳球蛋白（B-LG）、κ-酪蛋白（CSN3）、二酰甘油酰基转移酶1（DGAT1）、催乳素（PRL）、生长激素（GH）和垂体特异性转录因子1（PIT1）基因多态性及其对产奶性状影响相关的单一估计值。本荟萃分析的目的是研究荷斯坦奶牛中B-LG、CSN3、DGAT1、GH、PIT1和PRL基因多态性与产奶性状之间的关联。我们在2002年至2022年期间进行了广泛的搜索。使用Stata 11.2软件进行统计分析。应用了共显性（AA与AB、AA与BB、AB与BB）、显性（AA + AB与BB）、隐性（AA与AB + BB）和完全超显性（AA + BB与AB）等遗传模型。B-LG基因型与产奶量之间的荟萃分析结果显示差异显著（P < 0.05），与乳脂和蛋白质含量之间差异极显著（P < 0.01）。在CSN3基因多态性中，A/A和A/B基因型对乳脂产量（P < 0.05）和蛋白质含量（P < 0.01）有显著影响。DGAT1基因多态性对产奶量、乳脂产量、蛋白质产量有显著影响（P < 0.05），对乳脂和蛋白质含量有高度显著影响（P < 0.01）。未检测到GH与产奶性状之间的显著关联（P > 0.05）。PIT1基因型多态性对产奶量（P < 0.05）和蛋白质含量（P < 0.01）有显著影响。PRL基因型多态性与产奶量（P < 0.05）、乳脂含量和蛋白质产量（P < 0.01）显著相关。B-LG、DGAT1、CSN3和PRL基因多态性可作为改善荷斯坦牛产奶性状的良好标记。
