Zhang Xiaodi, Zhao Yi, Guo Dafen, Luo Mingxian, Zhang Qing, Zhang Li, Zhang Dengshen
Department of Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.
Outpatient Department Office, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.
Cardiovasc Drugs Ther. 2024 Mar 4. doi: 10.1007/s10557-024-07564-2.
AMPK is considered an important protein signaling pathway that has been shown to exert prominent cardioprotective effects on the pathophysiological mechanisms of numerous diseases. Following myocardial infarction, severe impairment of cardiac function occurs, leading to complications such as heart failure and arrhythmia. Therefore, protecting the heart and improving cardiac function are important therapeutic goals after myocardial infarction. Currently, there is substantial ongoing research on exercise-centered rehabilitation training, positioning exercise training as a significant nonpharmacological approach for preventing and treating numerous cardiovascular diseases.
Previous studies have reported that exercise can activate AMPK phosphorylation and upregulate the AMPK signaling pathway to play a cardioprotective role in coronary artery disease, but the specific mechanism involved remains to be elucidated.
This review discusses the role and mechanism of the exercise-mediated AMPK pathway in improving postinfarction cardiac function through existing studies and describes the mechanism of exercise-induced myocardial repair of AMPK from multiple perspectives to formulate a reasonable and optimal exercise rehabilitation program for the prevention and treatment of myocardial infarction patients in the clinic.
AMPK被认为是一条重要的蛋白质信号通路，已被证明对多种疾病的病理生理机制具有显著的心脏保护作用。心肌梗死后，心脏功能会出现严重损害，导致心力衰竭和心律失常等并发症。因此，保护心脏和改善心脏功能是心肌梗死后重要的治疗目标。目前，以运动为中心的康复训练正在进行大量研究，将运动训练定位为预防和治疗多种心血管疾病的重要非药物方法。
先前的研究报道运动可激活AMPK磷酸化并上调AMPK信号通路，从而在冠状动脉疾病中发挥心脏保护作用，但具体机制仍有待阐明。
本综述通过现有研究探讨运动介导的AMPK途径在改善梗死后心脏功能中的作用和机制，并从多个角度描述运动诱导的AMPK心肌修复机制，以便在临床上为心肌梗死患者制定合理、优化的运动康复方案。
