The maximum likelihood estimation of haplotype frequencies of HLA and HLA-like systems and addition loci of genes with the different modes of inheritance.

Conventional formula for the estimation of haplotype frequencies proposed by Yasuda was extended for the haplotypes constituting three HLA loci and two additional loci of genes with codominant alleles. The computer programme FREHAP estimates 32 haplotype frequencies rijkmn by the method of maximum likelihood, as well as it calculates the marginal frequencies rijk.. and r...mn, the matrix of expected numbers and the value of chi-square for the goodness of fit. The FREHAP has been programmed in FORTRAN IV for a CDC CYBER 72 computer.