Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Division of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Sci Rep. 2024 Mar 4;14(1):5341. doi: 10.1038/s41598-024-55499-3.
To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up.
评估开放或腹腔镜供肾切术后供体长期肾残留体积与慢性肾脏病（CKD）进展的关系。这是一项回顾性观察研究，共纳入 452 名在泰国曼谷 Ramathibodi 医院接受开放或腹腔镜供肾切术的患者。研究跨越了长达 60 个月的监测期。通过计算机断层扫描确定剩余肾体积。收集并分析患者特征、手术技术、供肾侧和估算肾小球滤过率（eGFR）。在多变量分析中，肾残留体积超过原始体积的 50%与 CKD 发生的可能性增加相关，风险比（HR）为 1.675（P<0.05），男性性别风险比（HR）为 4.013（P<0.001）。此外，年龄也是发生 CKD 的一个较小风险因素，风险比（HR）为 1.107（P<0.001）。在长期随访中，较高的剩余肾体积、男性性别和年龄较大被确定为开放或腹腔镜供肾切术后发生 CKD 的独立危险因素。
