Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third Hospital, 100191, Beijing, China.
BMC Ophthalmol. 2024 Mar 4;24(1):99. doi: 10.1186/s12886-024-03334-8.
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.
A 72-year-old male patient presented to our hospital with progressive blurring of vision in the left eye for the past 4 months. Small white nodular lesions were observed on the iris and retinal surface of the left eye, with a white cloud-like opacity in the vitreous cavity.
The patient was eventually diagnosed with EBV-positive iris DLBCL after undergoing pathological and metagenomic tests. After injecting methotrexate in the left vitreous cavity and administering systemic and local antiviral treatments, the ocular lesions disappeared.
EBV infection, drug immunosuppression, and aging-related immune deterioration may play significant roles in the pathogenesis of EBV-positive iris DLBCL.
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a new subtype of DLBCL, which rarely occurs. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.
EB 病毒（EBV）阳性弥漫性大 B 细胞淋巴瘤（DLBCL）是一种相对罕见的 DLBCL 亚型。本文报告了 1 例接受穿透性角膜移植术后发生 EBV 阳性虹膜 DLBCL 的患者，并探讨其可能的发病机制。
1 名 72 岁男性因左眼视力进行性模糊 4 个月就诊。左眼虹膜和视网膜表面可见小白结节状病变，玻璃体内有白色云状混浊。
患者最终通过病理和宏基因组学检查被诊断为 EBV 阳性虹膜 DLBCL。经左玻璃体内注射甲氨蝶呤，并进行全身和局部抗病毒治疗后，眼部病变消失。
EBV 感染、药物免疫抑制和与年龄相关的免疫功能下降可能在 EBV 阳性虹膜 DLBCL 的发病机制中起重要作用。
EB 病毒（EBV）阳性弥漫性大 B 细胞淋巴瘤（DLBCL）是一种新的 DLBCL 亚型，很少见。本文报告了 1 例接受穿透性角膜移植术后发生 EBV 阳性虹膜 DLBCL 的患者，并探讨其可能的发病机制。
