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唐氏综合征、阻塞性睡眠呼吸暂停和甲状腺功能减退患者癫痫管理的多方面方法：病例报告

A Multifaceted Approach to Seizure Management in a Patient With Down Syndrome, Obstructive Sleep Apnea, and Hypothyroidism: A Case Report.

作者信息

Uchi Takafumi, Konno Shingo, Kihara Hideo, Sugimoto Hideki

机构信息

Department of Neurology, Toho University Ohashi Medical Center, Tokyo, JPN.

出版信息

Cureus. 2024 Mar 3;16(3):e55465. doi: 10.7759/cureus.55465. eCollection 2024 Mar.

DOI:10.7759/cureus.55465
PMID:38440203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10910299/
Abstract

In this case study, a 16-year-old male with Down syndrome (DS) faced persistent nocturnal seizures despite anti-seizure medications and treatment for concurrent hypothyroidism. Obstructive sleep apnea (OSA), a common issue in patients with Down syndrome, was revealed as a trigger of the seizures. The implementation of continuous positive airway pressure (CPAP) therapy along with medication adjustments led to a significant decrease in seizure frequency, highlighting the importance of a comprehensive approach to seizure management in patients with complex medical conditions.

摘要

在本病例研究中，一名患有唐氏综合征（DS）的16岁男性尽管服用了抗癫痫药物并接受了并发甲状腺功能减退症的治疗，但仍持续出现夜间癫痫发作。阻塞性睡眠呼吸暂停（OSA）是唐氏综合征患者的常见问题，被发现是癫痫发作的诱因。实施持续气道正压通气（CPAP）治疗并调整药物后，癫痫发作频率显著降低，凸显了对患有复杂疾病的患者进行全面癫痫管理方法的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/f9225aef0657/cureus-0016-00000055465-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/bd5d79982f60/cureus-0016-00000055465-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/f3521265418e/cureus-0016-00000055465-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/671884272aa3/cureus-0016-00000055465-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/f9225aef0657/cureus-0016-00000055465-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/bd5d79982f60/cureus-0016-00000055465-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/f3521265418e/cureus-0016-00000055465-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/671884272aa3/cureus-0016-00000055465-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/10910299/f9225aef0657/cureus-0016-00000055465-i04.jpg

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本文引用的文献

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Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity.阻塞性睡眠呼吸暂停与癫痫：理解共病的病理生理学
Int J Physiol Pathophysiol Pharmacol. 2023 Aug 15;15(4):105-114. eCollection 2023.
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Hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea: A systematic review and meta-analysis.唐氏综合征合并阻塞性睡眠呼吸暂停青少年的舌下神经刺激：一项系统评价和荟萃分析。
Front Neurol. 2022 Oct 25;13:1037926. doi: 10.3389/fneur.2022.1037926. eCollection 2022.
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Effects of Obstructive Sleep Apnea on Epilepsy, and Continuous Positive Airway Pressure as a Treatment Option.
阻塞性睡眠呼吸暂停对癫痫的影响以及持续气道正压通气作为一种治疗选择
J Clin Med. 2022 Apr 6;11(7):2063. doi: 10.3390/jcm11072063.
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Sleep Disorders in Adults with Down Syndrome.唐氏综合征成人的睡眠障碍
J Clin Med. 2021 Jul 6;10(14):3012. doi: 10.3390/jcm10143012.
5
Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity.唐氏综合征中的癫痫：一种高度普遍的合并症。
J Clin Med. 2021 Jun 24;10(13):2776. doi: 10.3390/jcm10132776.
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Sleep and Epilepsy: a Focused Review of Pathophysiology, Clinical Syndromes, Co-morbidities, and Therapy.睡眠与癫痫：病理生理学、临床综合征、共病及治疗的专题综述。
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Epileptic Spasms in Patients With Down Syndrome: Experiences From Caregivers.唐氏综合征患者的癫痫发作：照顾者的经验。
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