一例肾侵袭性混合上皮和间质肿瘤伴恶性转化的病例报告。

A case report of aggressive mixed epithelial and stromal tumor of the kidney with malignant transformation.

作者信息

Ansari Djafari Anahita, Rahnama Hossein, Javanmard Babak, Hojjati Seyyed Ali, Salarinejad Sareh

机构信息

Laser Application in Medical Sciences Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Urol Case Rep. 2024 Feb 22;53:102689. doi: 10.1016/j.eucr.2024.102689. eCollection 2024 Mar.

DOI:10.1016/j.eucr.2024.102689

PMID:38440418

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10909693/

Abstract

Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare benign kidney tumor. In rare cases, malignant transformation, such as sarcomatoid features indicates poor clinical outcomes. In this study, we will describe a 45 years old man with a diagnosis of MESTK with malignant transformation of the sarcomatoid component, after right radical nephrectomy. The patient underwent chemotherapy with adriamycin, ifosfamide, and granulocyte-colony stimulating factor (G-CSF). The radiological characteristics of MESTK can pose diagnostic challenges due to its non-unique radiological appearance. The presence of sarcomatoid transformation is a hallmark feature of malignant MESTK which can be very aggressive.

摘要

肾混合上皮和间质瘤（MESTK）是一种罕见的良性肾肿瘤。在罕见情况下，恶性转化，如肉瘤样特征提示临床预后不良。在本研究中，我们将描述一名45岁男性，其诊断为伴有肉瘤样成分恶性转化的MESTK，行右肾根治性切除术后情况。该患者接受了阿霉素、异环磷酰胺和粒细胞集落刺激因子（G-CSF）化疗。MESTK的放射学特征因其不具有独特的放射学表现而可能带来诊断挑战。肉瘤样转化的存在是恶性MESTK的标志性特征，其可能具有很强的侵袭性。