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拉杰果德市民医院在新冠疫情时代报告的真菌感染呈指数级上升:一项回顾性研究。

Exponential Rise of Fungal Infection Reported in Rajkot Civil Hospital in Covid Pandemic Era: A Retrospective Study.

作者信息

Vasani Ankita, Mistry Sejal, Shah Rushil

机构信息

PDU Medical College, Rajkot, Gujarat India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1-4. doi: 10.1007/s12070-023-03743-z. Epub 2023 Aug 4.

Abstract

Mucormycosis is a rare but serious angio-invasive infection caused by a group of fungi called mucormycetes. Mucormycosis is an aggressive, life-threatening infection requiring prompt diagnosis and early treatment. Wide spread use of steroid and higher antibiotics may cause immune irregulation in post covid patients. A hallmark of mucormycosis infection is the presence of extensive angioinvasion with resultant vessel thrombosis and tissue necrosis. We reported exponential rising cases of fungal infection in covid pandemic era. Here we published epidemiological data of 773 fungal infected cases operated in ENT department of PDU Medical college, Rajkot in 2021. We have documented patients demographic data with comorbidity, paranasal sinuses with orbital, palatal and cerebral involvement, evaluation method, surgical and post surgical management protocol which we followed in our institute to treat all cases. We got promising result in terms of survival and less morbidity. Early presentation, less comorbidity, proper evaluation and immediate debridement with systemic antifungal coverage for adequate duration proved to be mainstay treatment of fungal infection in covid pandemic era.

摘要

毛霉病是一种由称为毛霉菌的一类真菌引起的罕见但严重的血管侵袭性感染。毛霉病是一种侵袭性、危及生命的感染,需要及时诊断和早期治疗。类固醇和高级抗生素的广泛使用可能导致新冠后患者的免疫失调。毛霉病感染的一个标志是存在广泛的血管侵袭,导致血管血栓形成和组织坏死。我们报告了新冠大流行时代真菌感染病例呈指数级上升。在此,我们公布了2021年在拉杰科特PDU医学院耳鼻喉科接受手术的773例真菌感染病例的流行病学数据。我们记录了患者的人口统计学数据以及合并症情况、鼻窦伴眼眶、腭部和脑部受累情况、评估方法、我们所在机构用于治疗所有病例的手术及术后管理方案。在生存和降低发病率方面我们取得了令人满意的结果。在新冠大流行时代,早期就诊、较少的合并症、恰当评估以及立即清创并给予足够疗程的全身性抗真菌治疗被证明是真菌感染的主要治疗方法。

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