Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China.
Department of Clinical Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong Engineering & Technology Research Center for Pediatric Drug Development, Shandong Medicine & Health Key Laboratory of Clinical Pharmacy, Jinan, 250014, People's Republic of China.
Future Microbiol. 2024 Mar;19:355-372. doi: 10.2217/fmb-2023-0168. Epub 2024 Mar 5.
can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against planktonic cells and biofilms. We also summarize the possible inhibitory mechanisms, involving cell adhesion inhibition, membrane fracture, biofilm disruption and DNA disruption. We believe this can provide the basis for further research against biofilm-associated infections.
可引起局部感染，如脓肿和肺炎，以及全身感染，如菌血症和败血症。特别是耐甲氧西林的 经常表现出多种药物耐药性，这成为一个主要的临床挑战。耐甲氧西林 抗生素耐药性最常见的原因之一是生物膜的存在。从不同物种中提取的天然抗菌肽在对抗 生物膜方面显示出了有效性。在这篇综述中，我们总结了抗菌肽对 浮游细胞和生物膜的抑制活性。我们还总结了可能的抑制机制，包括细胞黏附抑制、膜破裂、生物膜破坏和 DNA 破坏。我们相信这可以为进一步研究针对 生物膜相关感染提供依据。
