在急性缺血性脑卒中患者中多次测量血浆 LRG1 的预后能力。
Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients.
机构信息
Department of Neurology, Cangzhou Central Hospital, Cangzhou, 061001, China.
Department of CT Diagnosis, Cangzhou Central Hospital, Cangzhou, 061001, China.
出版信息
Biomark Med. 2024 Mar;18(5):181-190. doi: 10.2217/bmm-2023-0545. Epub 2024 Mar 5.
This study aimed to investigate the prognostic potency of LRG1 in acute ischemic stroke (AIS) patients. Plasma LRG1 levels were detected at admission and on days 3, 7 and 30 in 150 AIS patients. LRG1 positively correlated with total cholesterol (p = 0.016), triglycerides (p = 0.046), C-reactive protein (p < 0.001), TNF-α (p = 0.001) and IL-6 (p = 0.004). After admission, LRG1 showed a decreasing trend (p < 0.001). Interestingly, LRG1 levels at admission (p = 0.014), day 3 (p = 0.027), day 7 (p = 0.008) and day 30 (p = 0.002) were higher in patients with modified Rankin scale score ≥2 versus those with scores <2. The LRG1 levels at day 7 (p = 0.032) and day 30 (p = 0.023) were higher in patients with recurrence versus no recurrence. LRG1 correlates with blood lipids, inflammation and short-term prognosis of AIS.
本研究旨在探讨 LRG1 在急性缺血性脑卒中（AIS）患者中的预后价值。在 150 例 AIS 患者中，分别于入院时和第 3、7、30 天检测血浆 LRG1 水平。LRG1 与总胆固醇（p = 0.016）、甘油三酯（p = 0.046）、C 反应蛋白（p < 0.001）、TNF-α（p = 0.001）和 IL-6（p = 0.004）呈正相关。入院后，LRG1 呈下降趋势（p < 0.001）。有趣的是，入院时（p = 0.014）、第 3 天（p = 0.027）、第 7 天（p = 0.008）和第 30 天（p = 0.002）的 LRG1 水平在改良 Rankin 量表评分≥2 的患者中高于评分<2 的患者。第 7 天（p = 0.032）和第 30 天（p = 0.023）的 LRG1 水平在复发患者中高于无复发患者。LRG1 与血脂、炎症和 AIS 的短期预后相关。
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