Faculty of Medicine, Neurosurgery Department, Mansoura University, Mansoura, Egypt.
Faculty of Medicine, General Surgery Department, Mansoura University, Mansoura, Egypt.
Childs Nerv Syst. 2024 Jun;40(6):1771-1776. doi: 10.1007/s00381-024-06344-5. Epub 2024 Mar 5.
Post infective hydrocephalus (PIH) is a type of hydrocephalus which occurs after an infection of the brain or cerebrospinal fluid (CSF). Treatment of PIH requires temporary measures such as external ventricular drain (EVD) and ventriculosubgaleal shunt (VSGS) until CSF becomes clear and ready to implement VP shunt. Limited research has been done to explore the tradeoff between these approaches particularly in pediatric PIH patients. Our study compares the complications, mortality rates, and the cost of used resources of both procedures.
A prospective study was conducted for 18 months in which we compared between VSGS and EVD for management of PIH involving 42 randomized cases with 21 patients in group A operated by VSGS and 21 patients in group B operated by EVD.
Our results show a statistically significant difference between both groups in the duration of implementation of VSGS/EVD until resolution of infection occurs. Additionally, a higher rate of pediatric intensive care unit (PICU) admission and a longer length of hospital stay (LOS) were recorded among the EVD group. No statistically significant difference between the number of complications that happened in both despite variations in their forms. Moreover, both groups showed nearly similar mortality rates.
There is no significant difference in the rate of complications between VSGS and EVD for PIH. Based on that, VSGS emerges as a favorable and cost-effective option for the management of PIH which leads to less economic burden on patients and the country's health resources, especially in developing countries.
感染后脑积水(PIH)是一种在大脑或脑脊液(CSF)感染后发生的脑积水。PIH 的治疗需要临时措施,如外部脑室引流(EVD)和脑室-皮下分流(VSGS),直到 CSF 变清并准备好实施 VP 分流。目前,针对这两种方法的权衡,尤其是在儿科 PIH 患者中,研究还很有限。我们的研究比较了这两种方法的并发症、死亡率和所用资源的成本。
进行了一项为期 18 个月的前瞻性研究,比较了 VSGS 和 EVD 在治疗 PIH 中的作用,共有 42 例随机病例,其中 21 例患者接受 VSGS 手术(A 组),21 例患者接受 EVD 手术(B 组)。
我们的结果显示,在感染得到解决之前,实施 VSGS/EVD 的时间在两组之间存在统计学上的显著差异。此外,EVD 组的儿科重症监护病房(PICU)入院率和住院时间(LOS)都较长。尽管两种方法的并发症形式不同,但两组之间的并发症发生率没有统计学上的显著差异。此外,两组的死亡率几乎相似。
在 PIH 的治疗中,VSGS 和 EVD 的并发症发生率没有显著差异。基于这一点,VSGS 作为 PIH 治疗的一种有利且具有成本效益的选择,给患者和国家的卫生资源带来的经济负担较小,特别是在发展中国家。