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狼疮性肾炎及相关血栓性微血管病

[Lupus nephritis and associated thrombotic microangiopathy].

作者信息

Schuster Antonia, Banas Bernhard, Bergler Tobias

机构信息

Abteilung für Nephrologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Medizinische Klinik III-Nephrologie, Klinikum Ingolstadt, Ingolstadt, Deutschland.

出版信息

Z Rheumatol. 2024 Oct;83(8):675-678. doi: 10.1007/s00393-024-01489-9. Epub 2024 Mar 5.

Abstract

Lupus nephritis represents the most common manifestation of lupus of the solid organs and is associated with an increased risk of chronic kidney disease. The co-occurrence of lupus nephritis and thrombotic microangiopathy is described to be rare but implies the risk of fatal organ dysfunction. We report three patients in whom these two disease entities occurred in parallel, necessitating intensive immunosuppressive therapy, including complement blockade.

摘要

狼疮性肾炎是实体器官狼疮最常见的表现形式,与慢性肾脏病风险增加相关。狼疮性肾炎与血栓性微血管病同时出现的情况虽罕见,但意味着存在致命性器官功能障碍的风险。我们报告了三例这两种疾病同时发生的患者,需要强化免疫抑制治疗,包括补体阻断。

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