Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Transl Psychiatry. 2024 Mar 5;14(1):135. doi: 10.1038/s41398-024-02850-x.
Major depressive disorder (MDD) is a serious mental illness, characterized by disturbances of gut microbiome, it is required to further explore how the carbohydrate-active enzymes (CAZymes) were changed in MDD. Here, using the metagenomic data from patients with MDD (n = 118) and heath controls (HC, n = 118), we found that the whole CAZymes signatures of MDD were significantly discriminated from that in HC. α-diversity indexes of the two groups were also significantly different. The patients with MDD were characterized by enriched Glycoside Hydrolases (GHs) and Polysaccharide Lyases (PLs) relative to HC. A panel of makers composed of 9 CAZymes mainly belonging to GHs enabled to discriminate the patients with MDD and HC with AUC of 0.824. In addition, this marker panel could classify blinded test samples from the two groups with an AUC of 0.736. Moreover, we found that baseline 4 CAZymes levels also could predict the antidepressant efficacy after adjusted confounding factors and times of depressive episode. Our findings showed that MDD was associated with disturbances of gut CAZymes, which may help to develop diagnostic and predictive tools for depression.
重度抑郁症（MDD）是一种严重的精神疾病，其特征为肠道微生物组紊乱，需要进一步探索 MDD 中碳水化合物活性酶（CAZymes）是如何变化的。在这里，我们使用来自 MDD 患者（n=118）和健康对照者（HC，n=118）的宏基因组数据，发现 MDD 的整个 CAZymes 特征与 HC 明显不同。两组的α多样性指数也有显著差异。与 HC 相比，MDD 患者的糖基水解酶（GHs）和多糖裂解酶（PLs）更为丰富。由主要属于 GHs 的 9 种 CAZymes 组成的一组标志物能够以 0.824 的 AUC 区分 MDD 患者和 HC。此外，该标志物面板可以以 0.736 的 AUC 将两组的盲测样本分类。此外，我们发现基线时的 4 种 CAZymes 水平也可以在调整混杂因素和抑郁发作次数后预测抗抑郁药的疗效。我们的研究结果表明，MDD 与肠道 CAZymes 紊乱有关，这可能有助于开发用于诊断和预测抑郁症的工具。
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