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硝唑尼特难治性隐孢子虫病并发儿童伯基特淋巴瘤

Nitazoxanide refractory cryptosporidiosis complicating Burkitt lymphoma in a child.

作者信息

Khan Salman, Das Arghya, Kataria Babita, Yadav Himanshu, Mirdha Bijay Ranjan

机构信息

Department of Microbiology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.

Department of Medical Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Trop Parasitol. 2024 Jan-Jun;14(1):50-53. doi: 10.4103/tp.tp_25_23. Epub 2024 Feb 15.

Abstract

species cause watery diarrhea in several vertebrate hosts, including humans. Most apparently, immunocompetent-infected individuals remain asymptomatic, whereas immunocompromised may develop severe or chronic cryptosporidiosis. We report here the case of a 6-year-old girl undergoing chemotherapy for Burkitt lymphoma who experienced multiple episodes of watery diarrhea during her hospital stay. Microscopic examination of her stool sample revealed oocysts of species. The rapid immunochromatographic test was also positive for species. She was treated with nitazoxanide for 3 weeks, which failed to provide both clinical improvement and parasitological clearance. This case highlights the importance of treatment failure in human cryptosporidiosis.

摘要

多种物种可在包括人类在内的多种脊椎动物宿主中引起水样腹泻。最明显的是,免疫功能正常的感染者通常无症状,而免疫功能低下者可能会发展为严重或慢性隐孢子虫病。我们在此报告一例6岁接受伯基特淋巴瘤化疗的女孩,她在住院期间经历了多次水样腹泻。对其粪便样本进行显微镜检查发现了该物种的卵囊。快速免疫层析试验对该物种也呈阳性。她接受了硝唑尼特治疗3周,但未能实现临床改善和寄生虫清除。该病例凸显了人类隐孢子虫病治疗失败的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3985/10911182/b5fc21e85f1d/TP-14-50-g001.jpg

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