比较鼻咽拭子和下呼吸道标本的聚合酶链反应检测在肺炎诊断中的应用
Comparing Polymerase Chain Reaction Testing of Nasopharyngeal Swab and Lower Respiratory Tract Specimens for the Diagnosis of Pneumonia.
作者信息
Chew Rusheng, Tozer Sarah, Ulett Kimberly, Paterson David L, Whiley David, Sloots Theo, Fielding David, Zappala Christopher, Bashirzadeh Farzad, Hundloe Justin, Bletchley Cheryl, Woods Marion L
机构信息
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
Mathematical and Economic Modelling Department, Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand.
出版信息
Open Forum Infect Dis. 2024 Feb 2;11(3):ofae071. doi: 10.1093/ofid/ofae071. eCollection 2024 Mar.
Abstract
Using nasopharyngeal (NP) swab samples instead of lower respiratory tract specimens for polymerase chain reaction (PCR) to diagnose pneumonia (PJP) may be better tolerated and improve diagnostic accessibility. In this 2-year Australian retrospective cohort study of patients with clinically suspected PJP, PCR on NP swab samples had perfect specificity but low sensitivity (0.66).
摘要
使用鼻咽（NP）拭子样本而非下呼吸道标本进行聚合酶链反应（PCR）以诊断肺孢子菌肺炎（PJP），可能耐受性更好且能提高诊断的可及性。在这项针对临床疑似PJP患者的为期2年的澳大利亚回顾性队列研究中，NP拭子样本的PCR具有完美的特异性，但敏感性较低（0.66）。
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