氧化还原中性锌催化的重氮环丙烷与给体-受体氮丙啶的[1,4]-氢迁移/环化串联反应。
Redox-neutral zinc-catalyzed cascade [1,4]-H shift/annulation of diaziridines with donor-acceptor aziridines.
作者信息
Samantaray Swati, Maharana Prabhat Kumar, Kar Subhradeep, Saha Sharajit, Punniyamurthy Tharmalingam
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.
出版信息
Chem Commun (Camb). 2024 Mar 21;60(25):3441-3444. doi: 10.1039/d4cc00226a.
PMID:38445334
Abstract
The coupling of diaziridines with donor-acceptor aziridines (DAAs) has been achieved using Zn-catalysis to furnish imidazopyrazole-4,4-dicarboxylates [1,4]-hydride shift. The use of Zn-catalysis, [1,4]-hydride shift, natural product modification and a late-stage molecular docking study are important practical features.
摘要
利用锌催化实现了重氮环丙烷与供体-受体氮丙啶（DAA）的偶联，以提供咪唑并吡唑-4,4-二羧酸酯[1,4]-氢迁移。锌催化、[1,4]-氢迁移、天然产物修饰和后期分子对接研究的应用是重要的实际特点。
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