Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India.
Bioanalysis. 2024;16(8):279-305. doi: 10.4155/bio-2023-0256. Epub 2024 Mar 6.
Covalent organic frameworks (COFs) have much potential in the field of analytical separation research due to their distinctive characteristics, including easy modification, low densities, large specific surface areas and permanent porosity. This article provides a historical overview of the synthesis and broad perspectives on the applications of COFs. The use of COF-based membranes in gas separation, water treatment (desalination, heavy metals and dye removal), membrane filtration, photoconduction, sensing and fuel cells is also covered. However, these COFs also demonstrate great promise as solid-phase extraction sorbents and solid-phase microextraction coatings. In addition to various separation applications, this work aims to highlight important advancements in the synthesis of COFs for chiral and isomeric compounds.
共价有机框架（COFs）由于其独特的特性，包括易于修饰、低密度、大比表面积和永久孔隙率，在分析分离研究领域具有很大的潜力。本文提供了 COFs 的合成历史概述和广泛的应用前景。本文还介绍了基于 COF 的膜在气体分离、水处理（脱盐、重金属和染料去除）、膜过滤、光导、传感和燃料电池中的应用。然而，这些 COFs 作为固相萃取吸附剂和固相微萃取涂层也具有很大的应用潜力。除了各种分离应用外，这项工作还旨在强调 COFs 在手性和异构体化合物合成方面的重要进展。
