Pediatric Hematology/Oncology Unit, Kaplan Medical Center, Rehovot, Israel, Affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel.
J Pediatr Hematol Oncol. 2024 Apr 1;46(3):117-124. doi: 10.1097/MPH.0000000000002848. Epub 2024 Mar 5.
Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of pediatric NPC includes chemotherapy and radiotherapy. Most studies on the treatment of pediatric NPC are single-arm studies. With current treatment protocols survival rates for patients with nonmetastatic disease exceed 80%, although most children will have long-term treatment-related late effects. Efforts to reduce early and late toxicities include reduced radiotherapy doses in children with good responses to induction chemotherapy. Further studies are needed to evaluate the role of immunotherapy in both the primary setting and in children with progressive or relapsed disease. This review summarizes current clinical approaches to the treatment of pediatric NPC.
鼻咽癌（NPC）是一种罕见且局部侵袭性强的儿童癌症。儿童 NPC 的治疗包括化疗和放疗。大多数关于儿童 NPC 治疗的研究都是单臂研究。目前的治疗方案对无转移疾病患者的生存率超过 80%，尽管大多数儿童将有长期的治疗相关晚期效应。减少早期和晚期毒性的努力包括对诱导化疗反应良好的儿童减少放疗剂量。需要进一步研究来评估免疫疗法在原发性疾病和进展性或复发性疾病儿童中的作用。这篇综述总结了目前治疗儿童 NPC 的临床方法。
