Winona State University, United States of America.
Pharmacol Biochem Behav. 2024 May;238:173740. doi: 10.1016/j.pbb.2024.173740. Epub 2024 Mar 4.
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may have some benefit in preventing relapse. A previous study successfully employed the NMDA receptor antagonist MK-801 in preventing the development of sign-tracking (but not goal-tracking) in a conditioned approach task. In this study, we focused on whether MK-801 would have similar effects on previously established sign-tracking behavior. MK-801 was administered after training in a standard sign-/goal-tracking task using a retractable lever as a conditioned stimulus and a sucrose pellet as unconditioned stimulus. It was found that MK-801 increased measures of both sign- and goal-tracking in subjects who had previously learned the task. The NMDA receptor appears to play a complex role in governing behavior related to sign-tracking.
标记跟踪是一种巴甫洛夫条件作用的接近行为，被认为对理解线索驱动的药物使用复发很重要，减少标记跟踪的策略可能对预防复发有一定的益处。先前的一项研究成功地使用 NMDA 受体拮抗剂 MK-801 防止了条件接近任务中标记跟踪（但不是目标跟踪）的发展。在这项研究中，我们专注于 MK-801 是否会对先前建立的标记跟踪行为产生类似的影响。在使用可缩回杆作为条件刺激和蔗糖丸作为非条件刺激的标准标记/目标跟踪任务中进行训练后，给予 MK-801。结果发现，MK-801 增加了先前学习过该任务的受试者的标记和目标跟踪的测量值。NMDA 受体似乎在控制与标记跟踪相关的行为方面发挥着复杂的作用。
