Uraisami Keiichi, Saburi Masuho, Kawano Katsuya, Kodama Yosuke, Takata Hiroyuki, Miyazaki Yasuhiko, Wada Junpei, Urabe Shogo, Ohtsuka Eiichi
Department of Hematology, Oita Prefectural Hospital.
Department of Clinical Laboratory Technology, Oita Prefectural Hospital.
Rinsho Ketsueki. 2024;65(2):95-98. doi: 10.11406/rinketsu.65.95.
A 72-year-old woman presented with generalized lymphadenopathies and plasmacytosis accompanied by polyclonal hypergammopathy. F-fluorodeoxyglucose positron emission tomography (FDG-PET) showed FDG accumulation in the systemic lymph nodes, spleen, and multiple bones. Human immunodeficiency virus antibody was negative. Lymph node histologic findings showed a monotonous population of plasma cells with a starry-sky appearance. The cells were positive for CD19, λ, and Epstein-Barr virus-encoded RNA, and negative for CD20 and CD56. The MIB-1 index was 80%. A diagnosis of plasmablastic lymphoma with plasmacytosis and polyclonal hypergammopathy was made, and complete metabolic response was achieved after six cycles of dose-adjusted-EPOCH therapy (etoposide, prednisolone, vincristine, cyclophosphamide, and doxorubicin).
一名72岁女性出现全身淋巴结肿大和浆细胞增多症，并伴有多克隆高丙种球蛋白血症。氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）显示全身淋巴结、脾脏和多根骨骼中有FDG积聚。人类免疫缺陷病毒抗体为阴性。淋巴结组织学检查结果显示为一群形态单一的浆细胞，呈满天星外观。这些细胞CD19、λ和爱泼斯坦-巴尔病毒编码RNA呈阳性，CD20和CD56呈阴性。MIB-1指数为80%。诊断为伴有浆细胞增多症和多克隆高丙种球蛋白血症的浆母细胞淋巴瘤，在接受六个周期的剂量调整EPOCH治疗（依托泊苷、泼尼松龙、长春新碱、环磷酰胺和阿霉素）后实现了完全代谢缓解。
