Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013.
Department of Clinical Laboratory, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Dec 28;48(12):1937-1944. doi: 10.11817/j.issn.1672-7347.2023.220547.
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome in which tumor-induced osteochondrosis is a metabolic bone disease caused by increased renal excretion of phosphorus due to excessive secretion of fibroblast growth factor 23 (FGF23) by tumor tissue. We report here a rare case of TIO in which the tumor was found in the hyoid body and the patient had tertiary hyperparathyroidism. The patient's symptoms did not improve after removal of the tumor from the hyoid body, and the patient's hypophosphatemia was gradually improved after subsequent removal of the left parathyroid gland. TIO derived from the tongue tumor is very rare, and also subsequent tertiary hyperparathyroidism is even rarer. This report helps to improve the understanding of TIO and provides reference in the diagnosis and treatment of TIO.
肿瘤相关性骨软化症（TIO）是一种罕见的副瘤综合征，其中肿瘤诱导性骨软骨病是一种代谢性骨病，由肿瘤组织过度分泌成纤维细胞生长因子 23（FGF23）导致肾脏磷排泄增加引起。我们在此报告一例罕见的 TIO 病例，肿瘤位于舌骨，患者患有三级甲状旁腺功能亢进症。患者的症状在切除舌骨肿瘤后并未改善，随后切除左甲状旁腺后，患者的低磷血症逐渐改善。来源于舌肿瘤的 TIO 非常罕见，并且继发的三级甲状旁腺功能亢进症更为罕见。本报告有助于提高对 TIO 的认识，并为 TIO 的诊断和治疗提供参考。
