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Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies.

作者信息

Zhao Wanbing, Liu Kaien, Fan Yun, Zhao Qinyue, Tao Youqi, Zhang Mengwei, Gan Linhua, Yu Wenbo, Sun Bo, Li Dan, Liu Cong, Wang Jian

机构信息

Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

出版信息

Cell Discov. 2024 Mar 7;10(1):27. doi: 10.1038/s41421-023-00637-w.

DOI:10.1038/s41421-023-00637-w
PMID:38448404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10917778/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3b5/10917778/f99076b28320/41421_2023_637_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3b5/10917778/f99076b28320/41421_2023_637_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3b5/10917778/f99076b28320/41421_2023_637_Fig1_HTML.jpg

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本文引用的文献

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Front Neurosci. 2023 Apr 20;17:1149761. doi: 10.3389/fnins.2023.1149761. eCollection 2023.
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The Sensitivity of Tau Tracers for the Discrimination of Alzheimer's Disease Patients and Healthy Controls by PET.正电子发射断层扫描（PET）中 tau 示踪剂对阿尔茨海默病患者与健康对照者的区分敏感性。
Biomolecules. 2023 Feb 3;13(2):290. doi: 10.3390/biom13020290.
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Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases.
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Inducers and modulators of protein aggregation in Alzheimer's disease - Critical tools for understanding the foundations of aggregate structures.阿尔茨海默病中蛋白质聚集的诱导剂和调节剂——理解聚集体结构基础的关键工具。
Neurotherapeutics. 2025 Apr;22(3):e00512. doi: 10.1016/j.neurot.2024.e00512. Epub 2025 Jan 3.
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Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders.用于神经退行性疾病中tau蛋白和α-突触核蛋白成像的正电子发射断层扫描（PET）示踪剂开发策略。
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Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research.致病性纤维的冷冻电镜结构及其对神经退行性疾病研究的影响。
Neuron. 2024 Jul 17;112(14):2269-2288. doi: 10.1016/j.neuron.2024.05.012. Epub 2024 Jun 3.
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