基于双样本孟德尔随机化研究探讨血液代谢物和代谢途径对格雷夫斯病和格雷夫斯眼病的因果关系。
Causality of blood metabolites and metabolic pathways on Graves' disease and Graves' ophthalmopathy: a two-sample Mendelian randomization study.
机构信息
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
出版信息
Endocrine. 2024 Aug;85(2):786-793. doi: 10.1007/s12020-024-03761-z. Epub 2024 Mar 6.
OBJECTIVES
There is ample that metabolic dysregulation is involved in Graves' disease (GD) and Graves' ophthalmopathy (GO). Recent studies have identified numerous metabolites associated with GD and GO. However, the causal impact of metabolites on GD and GO remains to be investigated.
METHODS
This two-sample Mendelian randomization (MR) analysis investigated the causal relationships between 486 blood metabolites and GD and GO. Sensitivity analysis was also performed to examine heterogeneity and pleiotropy.
RESULTS
MR analysis showed that 9 and 13 metabolites were associated with GD and GO, respectively, each meeting the nominal significance criteria (inverse variance weighted, p < 0.05). Additionally, four metabolic pathways were identified for each condition using network-based MetaboAnalyst 5.0.
CONCLUSIONS
The metabolites and pathways discovered in this study could serve as circulating metabolic biomarkers for clinical screening and prevention of GD and GO. They can be also used for further studies on the mechanisms and drug targets in GD and GO.
目的
代谢失调与格雷夫斯病（GD）和格雷夫斯眼病（GO）密切相关。已有大量研究鉴定出与 GD 和 GO 相关的多种代谢物。然而，代谢物对 GD 和 GO 的因果影响仍有待研究。
方法
本两样本孟德尔随机化（MR）分析研究了 486 种血液代谢物与 GD 和 GO 之间的因果关系。还进行了敏感性分析以检查异质性和多效性。
结果
MR 分析显示，分别有 9 种和 13 种代谢物与 GD 和 GO 相关，每种代谢物均符合名义显著标准（逆方差加权，p<0.05）。此外，使用网络基 MetaboAnalyst 5.0 为每种情况确定了四个代谢途径。
结论
本研究发现的代谢物和途径可作为 GD 和 GO 的临床筛查和预防的循环代谢生物标志物。它们也可用于进一步研究 GD 和 GO 的机制和药物靶点。
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