From the Division of Immunology/Allergy Section, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio.
United States Environmental Protection Agency, Cincinnati, Ohio, and.
Allergy Asthma Proc. 2024 Mar 1;45(2):108-111. doi: 10.2500/aap.2024.45.230093.
Atopic dermatitis (AD) is an inflammatory skin disease caused by allergen exposures and estimated to affect ∼20% of children. Children in urban areas have a higher prevalence of AD compared with those living outside of urban areas. AD is believed to lead to asthma development as part of the "atopic march." Our objective was to determine the sequential and chronological relationships between AD and asthma for children in an under-resourced community. The progression from AD to asthma in the under-resourced, urban community of Sun Valley, Colorado, was examined by assessing Medicaid data for the years 2016 to 2019 for a diagnosis of AD or asthma in children 6 and 7 years old. Pearson correlations between AD and asthma diagnoses were significant only with respect to AD at age 6 years compared with asthma 1 year later, at age 7 years. By studying a susceptible community with a consistent but mixed genetic background, we found sequential and chronological links between AD and asthma.
特应性皮炎(AD)是一种由过敏原暴露引起的炎症性皮肤病,据估计影响了约 20%的儿童。与居住在城市以外地区的儿童相比,城市地区的儿童 AD 患病率更高。AD 被认为会导致哮喘发展,这是“特应性进行曲”的一部分。我们的目的是确定资源匮乏社区中儿童 AD 和哮喘之间的顺序和时间关系。通过评估科罗拉多州桑谷市的医疗补助数据,我们研究了资源匮乏的城市社区中 AD 向哮喘的进展情况,这些数据涵盖了 2016 年至 2019 年 6 岁和 7 岁儿童的 AD 或哮喘诊断。只有在 6 岁时的 AD 与 1 年后 7 岁时的哮喘之间,AD 和哮喘诊断之间的 Pearson 相关性才具有统计学意义。通过研究一个具有一致但混合遗传背景的易感社区,我们发现了 AD 和哮喘之间的顺序和时间联系。