Wang I-Jen, Lin Tien-Jen
Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare; College of Medicine, National Yang-Ming University; China Medical University, Taipei, Taiwan.
Graduate Institute of Injury Prevention and Control, Taipei Medical University, Wan Fang Hospital, Taipei, Taiwan.
Ann Allergy Asthma Immunol. 2015 Jan;114(1):52-7. doi: 10.1016/j.anai.2014.10.019.
Little is known about the role of genetic and environmental modifiers in atopic march.
To investigate the effects of filaggrin (FLG) P478S polymorphisms and environmental factors on the risk of asthma in a cohort of children with atopic dermatitis (AD).
In 2010, 3,246 children from Childhood Environment and Allergic Diseases Cohort Study cohort were recruited. There were 485 children with AD who were invited for further clinical evaluation. Environmental exposures and skin prick tests for allergens were collected at 3 years of age and the development of asthma was determined at 6 years. Multivariate logistic regressions were performed to estimate the association between genetic and environmental factors and the development asthma in children with AD.
Of 397 children with AD who completed the follow-up, 97 developed asthma. After controlling for potential confounders, only mite sensitizations (odds ratio 1.89, 95% confidence interval 1.10-3.25) and the FLG TT genotype (odds ratio 2.26, 95% confidence interval 1.33-3.84) were significantly associated with the development of asthma in children with AD. Mite sensitizations and FLG variants had a synergistic effect on the development of asthma. When children with FLG variants were exposed to mite, the risk for asthma was compounded compared with those with FLG variants without mite exposure (odds ratio 3.58, 95% confidence interval 1.81-7.08).
Mite sensitization and the FLG TT genotype couldt be associated with the development of atopic march.
关于基因和环境修饰因子在特应性进程中的作用，人们了解甚少。
在一组患有特应性皮炎（AD）的儿童队列中，研究丝聚蛋白（FLG）P478S多态性和环境因素对哮喘风险的影响。
2010年，招募了来自儿童环境与过敏性疾病队列研究队列的3246名儿童。邀请了485名患有AD的儿童进行进一步的临床评估。在3岁时收集环境暴露情况和过敏原皮肤点刺试验结果，并在6岁时确定哮喘的发生情况。进行多变量逻辑回归分析，以评估基因和环境因素与AD儿童哮喘发生之间的关联。
在397名完成随访的AD儿童中，97名患了哮喘。在控制了潜在的混杂因素后，只有螨致敏（比值比1.89，95%置信区间1.10 - 3.25）和FLG TT基因型（比值比2.26，95%置信区间1.33 - 3.84）与AD儿童哮喘的发生显著相关。螨致敏和FLG变异对哮喘的发生有协同作用。与未接触螨的FLG变异儿童相比，接触螨的FLG变异儿童患哮喘的风险更高（比值比3.58，95%置信区间1.81 - 7.08）。
螨致敏和FLG TT基因型可能与特应性进程的发展有关。
