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[胃癌切除术后十年以上晚期复发一例]

[A Case of Late Recurrence of Gastric Cancer Over Ten Years Post Gastrectomy].

作者信息

Tsuchihashi Hiroshi, Okumura Satoru, Toyoda Sho, Hamano Genya, Yamamoto Kansuke, Yuu Ken, Ogawa Masao, Kawasaki Masayasu

机构信息

Dept. of Surgery, Bellland General Hospital.

出版信息

Gan To Kagaku Ryoho. 2024 Feb;51(2):171-173.

Abstract

A 72-year-old woman underwent a low anterior resection of the rectum and a total hysterectomy with a bilateral salpingo- oophorectomy simultaneously for rectal and ovarian cancer, respectively. The pathological diagnosis was a moderately differentiated adenocarcinoma of the rectum with some poorly differentiated components signet-ring cell components. A mucinous adenocarcinoma, with similar characteristics as that in the rectum, was found in the ovary. Intraoperative findings revealed no direct invasion between the rectum and ovaries, with no peritoneal dissemination. She was, therefore, diagnosed with synchronous double cancer. The rectal cancer was pT3N0M0, Stage Ⅱ and the ovarian cancer pStage Ⅰ. Adjuvant chemotherapy with capecitabine was performed for high-risk Stage Ⅱ rectal cancer. At 3.5 years after surgery, her CA19-9 level was high and pleural dissemination and para-aortic lymph node metastasis were confirmed on thoracoabdominal CT. Twelve years after the gastrectomy for gastric cancer, a comparison of the pathological specimens of her stomach at that time with the current pathological specimens revealed that the rectal and ovarian tumors were metastases of gastric cancer and that the current recurrence was a late recurrence of this disease. Late recurrence after gastrectomy, especially 10 years or more after surgery, is extremely rare.

摘要

一名72岁女性因直肠癌和卵巢癌分别接受了直肠低位前切除术和全子宫切除术并同时进行双侧输卵管卵巢切除术。病理诊断为直肠中分化腺癌,伴有一些低分化成分即印戒细胞成分。在卵巢中发现了黏液腺癌,其特征与直肠中的相似。术中发现直肠和卵巢之间无直接侵犯,无腹膜播散。因此,她被诊断为同时性双癌。直肠癌为pT3N0M0,Ⅱ期,卵巢癌为Ⅰ期。对高危Ⅱ期直肠癌进行了卡培他滨辅助化疗。术后3.5年,她的CA19-9水平升高,胸腹部CT证实有胸膜播散和主动脉旁淋巴结转移。在因胃癌行胃切除术后12年,将当时她的胃病理标本与当前病理标本进行比较,发现直肠和卵巢肿瘤是胃癌转移灶,且当前复发是该疾病的晚期复发。胃切除术后的晚期复发,尤其是术后10年或更长时间,极为罕见。

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