Al Qurashi Mansour, Al-Khotani Abdulaziz, Mohtisham Farzeen, AlRaddadi Eman, AlShaikh Heba, Hakami Alqassem Y, Aga Syed Sameer
Department of Pediatrics, Ministry of National Guard Health Affairs (MNGHA), King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), WR King Abdulaziz Medical City, Jeddah, Saudi Arabia.
King Abdullah International Medical Research Centre (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Case Rep Pediatr. 2024 Feb 28;2024:2255756. doi: 10.1155/2024/2255756. eCollection 2024.
Ischemic limb lesions occasionally occur in neonates admitted to neonatal intensive care units. Known risk factors include the placement of arterial catheters, arterial punctures to obtain blood samples, and the use of vasoactive/vasopressor medications for hypotension. Prolonged peripheral tissue ischemia may result in serious complications, and successful management depends on early detection, proper assessment, and the institution of appropriate intervention. Currently, there is no standard approach for the management of peripheral tissue ischemia in extreme preterm infants. Topical nitroglycerine use is one of the promising options used to manage ischemic limb injuries in neonates, as demonstrated in several case reports. We report a case of digital ischemia in an extreme preterm infant with no clear risk factors except extreme prematurity, which recovered after topical nitroglycerine therapy.
入住新生儿重症监护病房的新生儿偶尔会出现肢体缺血性病变。已知的风险因素包括动脉导管的放置、为获取血样进行的动脉穿刺，以及使用血管活性/血管加压药物治疗低血压。外周组织长时间缺血可能导致严重并发症，而成功的治疗取决于早期发现、正确评估以及采取适当的干预措施。目前，对于极早产儿外周组织缺血的治疗尚无标准方法。如几份病例报告所示，局部使用硝酸甘油是用于治疗新生儿肢体缺血性损伤的有前景的选择之一。我们报告一例极早产儿出现手指缺血的病例，除极早产外无明确风险因素，经局部硝酸甘油治疗后恢复。
