剥除和 ICSI 之间的时间间隔对新鲜胚胎移植生殖结局的影响：一项回顾性研究。
Effect of the time interval between denudation and ICSI on fresh embryo transfer reproductive outcomes: a retrospective study.
机构信息
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
出版信息
Front Endocrinol (Lausanne). 2024 Feb 22;15:1283032. doi: 10.3389/fendo.2024.1283032. eCollection 2024.
PURPOSE
This study aims to determine if the incubation after oocyte denudation before Intra-cytoplasmic sperm injection (ICSI) affects the clinical pregnancy rate.
METHODS
This was a retrospective, consecutive data analysis of 1370 patients who underwent ICSI cycles at the Department of Reproductive Medicine of West China Second University of Sichuan University (Chengdu, Sichuan) between January 2020 and July 2022. The primary outcome was the clinical pregnancy rate. The second outcome included fertilization rate, biochemical pregnancy rate, and miscarriage rates.
RESULTS
A total of 1370 continuous fresh transferred ICSI cycles were analyzed. Multivariate linear regression and logistic regression analysis of factors related to clinical pregnancy rates revealed that clinical pregnancy rates were significantly associated with denudation (DEN)-ICSI time interval. Long DEN-ICSI intervals are associated with a higher clinical pregnancy rate during fresh embryo transfer.
CONCLUSION
The DEN-ICSI time interval is an independent factor for clinical outcomes in fresh ICSI transfer cycles.
目的
本研究旨在探讨卵母细胞去核后与胞浆内单精子注射（ICSI）之间的间隔时间是否影响临床妊娠率。
方法
这是一项回顾性、连续数据分析，共纳入 1370 名在 2020 年 1 月至 2022 年 7 月于四川大学华西第二医院生殖医学科接受 ICSI 周期的患者。主要结局是临床妊娠率。次要结局包括受精率、生化妊娠率和流产率。
结果
共分析了 1370 个连续的新鲜胚胎移植 ICSI 周期。对与临床妊娠率相关的因素进行多变量线性回归和逻辑回归分析显示，临床妊娠率与去核（DEN）-ICSI 时间间隔显著相关。较长的 DEN-ICSI 间隔与新鲜胚胎移植中较高的临床妊娠率相关。
结论
DEN-ICSI 时间间隔是新鲜 ICSI 移植周期临床结局的一个独立因素。
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