Mutiawati Endang, Kusuma Hendrix Indra, Fathima Raisha, Syahrul Syahrul, Musadir Nasrul
Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia.
Narra J. 2022 Dec;2(3):e93. doi: 10.52225/narra.v2i3.93. Epub 2022 Dec 10.
Headache is prevalent in coronavirus disease 2019 (COVID-19) patients. The main objective of this study was to compare the characteristics of COVID-19-associated headache to non-COVID-19 headache. The quality-of-life (QoL) and its associated determinants between COVID-19 and non-COVID-19 patients were also compared. A cross-sectional study was conducted in Banda Aceh, Indonesia. Headache and QoL were assessed using the International Classification of Headache Disorders, version 3 (ICHD-3), and the 36-item Short Form Health Survey (SF-36), respectively. Factors associated with poor QoL in COVID-19 and non-COVID-19 patients were examined using logistic regression. A total of 356 headache patients were included: 215 COVID-19 and 141 non-COVID-19 patients. Our data suggested that the headache in COVID-19 patients was bilateral; pain centered on one specific area with a pulsating or pressing sensation; pain intensity ranging from moderate to severe; and the frequency ranging from more than twice per week to every day. Non-COVID-19 headache was bilateral; pain centered on one side of the head resembling a migraine with pulsating or pressing sensation; mild to moderate pain intensity; and the frequency of one or two times per month. In COVID-19, low QoL was associated with unemployment status, having non-health-related jobs, having used painkillers to reduce the pain, having long duration of headache, having more frequency of attacks, and having headaches that were worsened by activities or light, and having additional symptom during a headache attach. In non-COVID-19 patients, poor QoL was associated with the use of painkillers, long duration of headache, and having conditions that aggravate the headache. To prevent long-term effects of headache associated with COVID-19, studies exploring the photobiology of headache are needed, along with the necessity of having standardised guideline on headache prevention.
头痛在2019冠状病毒病（COVID-19）患者中很常见。本研究的主要目的是比较COVID-19相关头痛与非COVID-19头痛的特征。还比较了COVID-19患者和非COVID-19患者的生活质量（QoL）及其相关决定因素。在印度尼西亚班达亚齐进行了一项横断面研究。分别使用《国际头痛疾病分类》第3版（ICHD-3）和36项简明健康调查（SF-36）评估头痛和生活质量。使用逻辑回归分析了COVID-19患者和非COVID-19患者中与生活质量差相关的因素。共纳入356例头痛患者：215例COVID-19患者和141例非COVID-19患者。我们的数据表明，COVID-19患者的头痛为双侧性；疼痛集中在一个特定区域，有搏动或压迫感；疼痛强度从中度到重度；发作频率从每周两次以上到每天发作。非COVID-19头痛为双侧性；疼痛集中在头部一侧，类似于偏头痛，有搏动或压迫感；疼痛强度为轻度至中度；发作频率为每月一至两次。在COVID-19患者中，生活质量低与失业状态、从事与健康无关的工作、使用止痛药减轻疼痛、头痛持续时间长、发作频率高、活动或光线会加重头痛以及头痛发作时有其他症状有关。在非COVID-19患者中，生活质量差与使用止痛药、头痛持续时间长以及有加重头痛的情况有关。为了预防与COVID-19相关的头痛的长期影响，需要开展探索头痛光生物学的研究，同时需要制定头痛预防的标准化指南。
