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LINC01134：一种在肝细胞癌中具有前景的预测标志物和治疗靶点的关键致癌基因。

LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma.

作者信息

Yu Yutian, Wang Jialing, Guo Qingfa, Luo Hongliang

机构信息

Department of Spleen and Stomach Diseases, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, China.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

出版信息

Front Oncol. 2024 Feb 21;14:1265762. doi: 10.3389/fonc.2024.1265762. eCollection 2024.

DOI:10.3389/fonc.2024.1265762
PMID:38450182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10915649/
Abstract

Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134's potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134's multifaceted roles, we aim to foster novel strategies in HCC management.

摘要

肝细胞癌（HCC）是胃肠道中一种主要的致命性恶性肿瘤。最近的进展凸显了长链非编码RNA（lncRNAs）在多种生物学途径和病理过程中的关键作用，尤其是在肿瘤发生过程中。LINC01134作为一种特定的lncRNA，因其在肝癌中的致癌潜力而备受关注。目前的研究强调了LINC01134在促进HCC发生和发展方面的潜力，以及在耐药性方面的显著影响。本综述全面探讨了LINC01134在HCC中的分子功能和调控机制，为治疗干预提供了新的视角。通过深入研究LINC01134的多方面作用，我们旨在推动HCC管理的新策略。

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本文引用的文献

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Disparities in stage at diagnosis for liver cancer in China.中国肝癌诊断分期的差异。
J Natl Cancer Cent. 2023 Jan 3;3(1):7-13. doi: 10.1016/j.jncc.2022.12.002. eCollection 2023 Mar.
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