Cho Wei-Ru, Wang Chih-Chi, Tsai Mu-Jung, Lin Chih-Che, Yen Yi-Hao, Chen Chien Hung, Kuo Yuan-Hung, Yao Chih-Chien, Hung Chao-Hung, Huang Pao-Yuan, Liu An-Che, Tsai Ming-Chao
Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Yunlin.
Division of General Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung.
Clin Med Insights Oncol. 2024 Mar 5;18:11795549241228232. doi: 10.1177/11795549241228232. eCollection 2024.
The risk of first recurrence of hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed to assess the incidence and prognostic factors for very late recurrence among patients who achieved 5 years' recurrence-free survival (RFS) after primary resection.
We retrospectively analyzed 337 patients with early-stage HCC underwent primary tumor resection and achieved more than 5 years' RFS.
A total of 77 patients (22.8%) developed very late recurrence. The cumulative very late recurrence rate increased from 6.9% and 11.7% to 16.6% at 6, 7, and 8 years, respectively. Patients stopped smoking had a higher rate of very late RFS.
The high rates of very late recurrence in HCC indicate that patients warrant continued surveillance, even after 5 recurrence-free years. Moreover, smoking is a risk factor for very late HCC recurrence, and quitting smoking may reduce the risk of very late recurrence.
肝细胞癌（HCC）根治性肝切除术后5至10年内首次复发的风险尚不清楚。我们旨在评估初次切除术后实现5年无复发生存（RFS）的患者中极晚期复发的发生率及预后因素。
我们回顾性分析了337例行原发性肿瘤切除且实现超过5年RFS的早期HCC患者。
共有77例患者（22.8%）发生极晚期复发。极晚期复发累积率在第6、7和8年分别从6.9%和11.7%升至16.6%。戒烟患者的极晚期RFS率更高。
HCC极晚期复发率高表明，即使在5年无复发后，患者仍需继续监测。此外，吸烟是HCC极晚期复发的危险因素，戒烟可能降低极晚期复发风险。
