Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy.
Università Cattolica del Sacro Cuore, 00168, Roma, Italy.
Obes Surg. 2024 May;34(5):1496-1504. doi: 10.1007/s11695-024-07109-4. Epub 2024 Mar 7.
Endoscopic sleeve gastroplasty (ESG) is a minimally invasive procedure that proved to be safe and effective in obesity treatment. However, not all subjects respond to treatment in the same way, and, with a view to personalized care, it is essential to identify predictors of success or failure.
A retrospective 2-year followed-up cohort of ESG subjects was analyzed to investigate the presence of any baseline or early indicators of long-term optimal or suboptimal ESG outcomes.
A total of 315 subjects (73% women) were included, with 73% of patients exhibiting an Excess weight loss percentage (%EWL) >25% at the 24 months. Neither demographic parameters (age and sex), smoking habits, and menopause in women nor the presence of comorbidities proved potential predictive value. Interestingly, the %EWL at 1 month after ESG was the strongest predictor of 24-month therapeutic success. Subsequently, we estimated an "early threshold for success" for 1 month-%EWL by employing Youden's index method.
ESG is a safe and effective bariatric treatment that can be offered to a wide range of subjects. Early weight loss seems to impact long-term ESG results significantly and may allow proper early post-operative care optimization.
内镜袖状胃切除术（ESG）是一种安全有效的减肥治疗方法。然而，并非所有患者对治疗的反应都相同，为了实现个性化治疗，确定成功或失败的预测因素至关重要。
对 ESG 患者进行了为期 2 年的回顾性随访队列分析，以调查是否存在任何基线或早期指标可预测长期的最佳或次佳 ESG 结果。
共纳入 315 例患者（73%为女性），73%的患者在 24 个月时体质量减轻率（%EWL）>25%。性别、吸烟习惯、女性更年期以及合并症等人口统计学参数或共存疾病均无潜在预测价值。有趣的是，ESG 术后 1 个月的 EWL 是预测 24 个月治疗成功的最强指标。随后，我们通过 Youden 指数法估计了 1 个月-%EWL 的“早期成功阈值”。
ESG 是一种安全有效的减肥治疗方法，可应用于广泛的患者群体。早期体重减轻似乎对长期 ESG 结果有显著影响，并可能允许优化术后早期的护理。
