相位角作为炎症性肠病患者肌肉质量的预测指标。
PHASE ANGLE AS A PREDICTOR OF MUSCLE MASS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
机构信息
Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, SC, Brasil.
Universidade Federal de Santa Catarina, Departamento de Análises Clínicas, Florianópolis, SC, Brasil.
出版信息
Arq Gastroenterol. 2024 Mar 4;61:e23095. doi: 10.1590/S0004-2803.246102023-95. eCollection 2024.
BACKGROUND
Malnutrition/sarcopenia is frequent in patients with inflammatory bowel diseases (IBD), and results in muscle catabolism, impacting treatment response, postoperative complications, and quality of life.
OBJECTIVE
This study aims to assess whether the phase angle (PhA) is a parameter for predicting reduced muscle mass in patients with IBD.
METHODS
Adult patients with IBD were included in this cross-sectional study. For the estimation of muscle mass and the calculation of the PhA, we used bioelectrical impedance analysis (BIA). Crohn's disease (CD) and ulcerative colitis (UC) activity scores were defined using the Harvey-Bradshaw index and partial Mayo score, respectively. The area under the ROC curve was calculated to identify the PhA cut-off point for reduced muscle mass.
RESULTS
The sample consisted of 145 patients, with 39 (26.9%) with IBD in the active phase. There was a correlation of the PhA with skeletal muscle mass (SMM) (rs 0.35, P<0.001) and with the skeletal muscle mass index (SMI) (rs 0.427, P<0.001), and the associations remained in the most active form (moderate or severe) of IBD. The ROC curve analysis indicated that the cut-offs points of the PhA ≤5.042 for female and PhA ≤6.079 for male can be used to predict muscle mass reduction.
CONCLUSION
The PhA can be considered a predictor of muscle mass reduction in IBD patients, and we can use it for screening and monitoring the evolution of malnutrition.
BACKGROUND
• This study aims to assess whether the phase angle is a parameter for predicting reduced muscle mass in patients with inflammatory bowel disease.
BACKGROUND
• There was a correlation of the phase angle with skeletal muscle mass and the associations remained in disease activity.
BACKGROUND
• The ROC curve analysis indicated that the cut-off point of the PhA ≤5.042° for women and PhA ≤6,079° for men can be used to predict muscle mass reduction.
BACKGROUND
• The phase angle can be considered a predictor of muscle mass reduction in inflammatory bowel disease.
背景
炎症性肠病（IBD）患者常出现营养不良/肌少症，导致肌肉分解代谢，影响治疗反应、术后并发症和生活质量。
目的
本研究旨在评估相位角（PhA）是否可作为预测 IBD 患者肌肉减少的参数。
方法
本横断面研究纳入了成年 IBD 患者。我们使用生物电阻抗分析（BIA）来评估肌肉量并计算 PhA。采用 Harvey-Bradshaw 指数和部分 Mayo 评分分别定义克罗恩病（CD）和溃疡性结肠炎（UC）的活动评分。计算 ROC 曲线下面积以确定 PhA 截断值与肌肉减少的相关性。
结果
本样本包括 145 例患者，其中 39 例（26.9%）处于 IBD 活动期。PhA 与骨骼肌量（SMM）（rs0.35，P<0.001）和骨骼肌质量指数（SMI）（rs0.427，P<0.001）呈相关性，且在 IBD 的最活跃形式（中重度）中仍存在相关性。ROC 曲线分析表明，女性 PhA≤5.042 和男性 PhA≤6.079 可用于预测肌肉减少。
结论
PhA 可作为 IBD 患者肌肉减少的预测指标，我们可使用它进行筛查并监测营养不良的演变。
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