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基于三苯胺的可逆机械变色 AIE 试剂用于水相介质中维生素 B2(核黄素)的选择性检测及细胞毒性。

A Reversible Mechanochromic AIEgen Based on Triphenylamine for the Selective Detection of Vitamin B2 (Riboflavin) in Aqueous Media and Histotoxicity.

机构信息

Department of Chemistry, Yashwantrao Chavan College Science, Karad, Maharashtra 415124, India.

Medicinal Chemistry Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, Maharashtra 416004, India.

出版信息

Chem Res Toxicol. 2024 Mar 18;37(3):455-464. doi: 10.1021/acs.chemrestox.3c00290. Epub 2024 Mar 7.

Abstract

()-Ethyl 2-cyano-3-(4'-(diphenyl amino)-[1,1'-biphenyl]-4-yl) acrylate (RSJ) is a novel luminogen based on triphenylamine. It has been fully synthesized and characterized, exhibiting an incredible photophysical phenomenon known as aggregation-induced emission (AIE). This work describes a fluorescent sensor that detects vitamin B2 in mixed aqueous media with high selectivity and a low limit of detection as well as a mechanism for reversible mechanochromic luminescence. Moreover, the molecule was validated for its nontoxicity in water using a histotoxicological study. Fish subjected to two different concentrations of the "novel luminogen" that displayed photophysical phenomena during sensing of vitamin B2 (riboflavin) in mixed aqueous media did not exhibit any significant differences in the structural makeup of their liver, kidney, gills, brain, and muscle tissues when compared with the control group.

摘要

()-乙基 2-氰基-3-(4'-(二苯基氨基)-[1,1'-联苯]-4-基)丙烯酸盐 (RSJ) 是一种基于三苯胺的新型发光体。它已经被完全合成和表征,表现出一种令人难以置信的光物理现象,称为聚集诱导发射 (AIE)。这项工作描述了一种荧光传感器,它可以在混合水介质中高选择性和低检测限检测维生素 B2,以及一种可逆机械变色发光的机制。此外,该分子在水中的非毒性已通过组织病理学研究得到验证。在混合水介质中检测维生素 B2(核黄素)时显示光物理现象的两种不同浓度的“新型发光体”对鱼类的肝脏、肾脏、鳃、大脑和肌肉组织的结构组成没有任何显著差异与对照组相比。

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