研究蝙蝠免疫力的转化潜力。

The translational potential of studying bat immunity.

作者信息

Baid Kaushal, Irving Aaron T, Jouvenet Nolwenn, Banerjee Arinjay

机构信息

Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.

Department of Clinical Laboratory Studies, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, Zhejiang 314400, China; BIMET - Biomedical and Health Translational Research Centre of Zhejiang Province; College of Medicine & Veterinary Medicine, The University of Edinburgh, Edinburgh, EH8 9YL, UK.

出版信息

Trends Immunol. 2024 Mar;45(3):188-197. doi: 10.1016/j.it.2024.01.007. Epub 2024 Mar 6.

DOI:10.1016/j.it.2024.01.007

PMID:38453577

Abstract

Molecular studies in bats have led to the discovery of antiviral adaptations that may explain how some bat species have evolved enhanced immune tolerance towards viruses. Accumulating data suggest that some bat species have also evolved remarkable features of longevity and low rates of cancer. Furthermore, recent research strongly suggests that discovering immune adaptations in bat models can be translated to develop immune modulators and recognize alternate therapeutic strategies for diseases affecting humans. We posit that research in bat immunology will lead to discoveries that can potentially be translated to improve health outcomes in humans.

摘要

对蝙蝠的分子研究已促成了抗病毒适应性的发现，这或许可以解释某些蝙蝠物种如何进化出对病毒更强的免疫耐受性。越来越多的数据表明，一些蝙蝠物种还进化出了显著的长寿特征和低癌症发生率。此外，近期研究有力地表明，在蝙蝠模型中发现的免疫适应性可转化用于开发免疫调节剂，并识别针对影响人类的疾病的替代治疗策略。我们认为，蝙蝠免疫学研究将带来有可能转化用于改善人类健康结果的发现。