School of Biological Sciences, Seoul National University, Seoul 08826, South Korea; Center for Systems Geroscience, Seoul National University, Seoul 08826, South Korea.
School of Biological Sciences, Seoul National University, Seoul 08826, South Korea; Center for Systems Geroscience, Seoul National University, Seoul 08826, South Korea.
Trends Endocrinol Metab. 2024 Aug;35(8):732-744. doi: 10.1016/j.tem.2024.02.008. Epub 2024 Mar 6.
Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.
细胞代谢是一个灵活和有弹性的网络，它常常决定着细胞的生理和病理状态，包括分化、癌症和衰老。癌症代谢的最新进展为通过靶向其改变的代谢来治疗癌症提供了巨大的机会。有趣的是，尽管衰老细胞（衰老过程的一个关键组成部分）处于稳定的生长停滞状态，但它们经历的代谢变化与癌症代谢相似。更深入地了解这些不同病理条件之间的相似性和差异性，将有助于确定哪种代谢重编程与衰老的治疗缺陷最相关。在这里，我们比较和对比了癌症和衰老的代谢，并讨论了如何将代谢疗法作为一种新的衰老治疗模式来实现健康衰老。
