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Linear stability for a free boundary problem modeling the growth of tumor cord with time delay.

作者信息

Zhou Haihua, Liu Yaxin, Wang Zejia, Song Huijuan

机构信息

School of Mathematics and Statistics, Hengyang Normal University, Hengyang 421010, China.

School of Mathematics and Statistics, Jiangxi Normal University, Nanchang 330022, China.

出版信息

Math Biosci Eng. 2024 Jan 15;21(2):2344-2365. doi: 10.3934/mbe.2024103.

DOI:10.3934/mbe.2024103
PMID:38454686
Abstract

This paper was concerned with a free boundary problem modeling the growth of tumor cord with a time delay in cell proliferation, in which the cell location was incorporated, the domain was bounded in $ \mathbb{R}^2 $, and its boundary included two disjoint closed curves, one fixed and the other moving and a priori unknown. A parameter $ \mu $ represents the aggressiveness of the tumor. We proved that there exists a unique radially symmetric stationary solution for sufficiently small time delay, and this stationary solution is linearly stable under the nonradially symmetric perturbations for any $ \mu > 0 $. Moreover, adding the time delay in the model leads to a larger stationary tumor. If the tumor aggressiveness parameter is bigger, the time delay has a greater effect on the size of the stationary tumor, but it has no effect on the stability of the stationary solution.

摘要

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