前列腺平滑肌肉瘤：两例报告及文献复习
Leiomyosarcoma of the Prostate: Report of Two Cases and Review of the Literature.
作者信息
Bettaieb Ons, Keskes Aicha, Llacer Moscardo Carmen
机构信息
Radiation Oncology Department, Farhat Hached Hospital, University of Sousse, Sousse, Tunisia.
Montpellier Cancer Institute, Federation of Radiation Oncology of Mediterranean Occitanie, University Montpellier, INSERM U1194 IRCM, Montpellier, France.
出版信息
Case Rep Oncol. 2024 Mar 7;17(1):454-462. doi: 10.1159/000535425. eCollection 2024 Jan-Dec.
INTRODUCTION
Leiomyosarcoma (LMS) of the prostate is an extremely rare and aggressive tumor that presents with nonspecific signs and symptoms. Treatment guidelines are not yet established.
CASE PRESENTATION
We report two cases of LMS of the prostate. The presenting symptom was hematuria, and diagnosis was ascertained through a transurethral resection of the prostate for the 2 patients. The treatment course consisted of three courses of chemotherapy with gemcitabine and docetaxel, radical prostatectomy, and postoperative radiation therapy for the first patient and three courses of gemcitabine and radiation therapy of the prostate and the whole pelvis for the second patient. The follow-up of our 2 patients was 9 and 12 months, respectively. Recurrence occurred 10 months after treatment completion for the second case. No recurrence was noticed in the first case.
CONCLUSION
These two cases highlight the importance of a multimodal approach to yield the best outcomes.
引言
前列腺平滑肌肉瘤（LMS）是一种极其罕见且侵袭性强的肿瘤，表现为非特异性体征和症状。目前尚未确立治疗指南。
病例报告
我们报告两例前列腺LMS。主要症状为血尿，通过经尿道前列腺切除术确诊这2例患者。治疗过程包括，第一例患者接受三个疗程的吉西他滨和多西他赛化疗、根治性前列腺切除术及术后放疗，第二例患者接受三个疗程的吉西他滨及前列腺和全盆腔放疗。我们的2例患者随访时间分别为9个月和12个月。第二例患者在治疗结束10个月后复发。第一例患者未发现复发。
结论
这两例病例凸显了采用多模式方法以取得最佳治疗效果的重要性。
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