Jiménez-Martínez Luis Enrique, Martínez-Cornelio Andrés, Fuziwara-Ruíz Seiichi, Hernández-Toriz Narciso, Tavares-García Juana Sonia
Department of Urology, Oncology Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Department of Pathology, Oncology Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Urol Case Rep. 2025 Jun 24;62:103110. doi: 10.1016/j.eucr.2025.103110. eCollection 2025 Sep.
Prostatic sarcoma accounts for 0.7 % of primary prostatic tumors, with leiomyosarcoma being the most common type (25 %). One-third of patients present with metastatic disease at diagnosis, and its expected behavior is that of an aggressive tumor. Additionally, the synchronous coexistence of two different primary tumors in the prostate is extremely rare in the literature. We present the case of a patient with two synchronous, distinct primary prostate malignancies: acinar adenocarcinoma and leiomyosarcoma. To our knowledge, this association has been reported in only two cases. Due to its rarity, there aren't standardized treatment guidelines, and its management requires a multidisciplinary approach.
前列腺肉瘤占原发性前列腺肿瘤的0.7%，其中平滑肌肉瘤是最常见的类型（25%）。三分之一的患者在诊断时即出现转移性疾病，其预期表现为侵袭性肿瘤。此外，前列腺中两种不同原发性肿瘤同步共存的情况在文献中极为罕见。我们报告了一例患有两种同步、不同原发性前列腺恶性肿瘤的患者：腺泡腺癌和平滑肌肉瘤。据我们所知，这种关联仅在两例病例中被报道过。由于其罕见性，尚无标准化的治疗指南，其治疗需要多学科方法。
