Konaklieva Monika I, Plotkin Balbina J
Department of Chemistry, American University, Washington, DC, United States.
Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, United States.
Front Mol Biosci. 2024 Feb 22;11:1338567. doi: 10.3389/fmolb.2024.1338567. eCollection 2024.
Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host's lipid metabolism.
微生物可以接管宿主细胞中的关键代谢途径，为其复制提供能量。这种相互作用为在抗菌药物研发中靶向宿主代谢途径（除了病原体特异性途径之外）提供了机会。宿主导向疗法（HDT）是一种新兴的抗感染治疗策略，它针对兼性和专性细胞内病原体在感染宿主细胞的进入、复制、逸出或持续存在过程中所利用的宿主细胞代谢。本综述概述了宿主脂质代谢，并将其与针对病毒和细菌感染的宿主导向疗法研发中的挑战联系起来，在这些感染中，病原体利用对宿主脂质酶很重要的物质，或者产生自身类似卵磷脂胆固醇酰基转移酶（LCAT）和脂蛋白脂肪酶（LPL）的物质，从而干扰人类宿主的脂质代谢。
