Tvorogova M G, Titov V N, Perova N V
Biull Eksp Biol Med. 1985 Dec;100(12):702-4.
Lipoproteinlipase (LPL) and lecithin-cholesterol-acyltransferase (LCAT) activity was studied in rats in conditions of drug-induced (Clofibrat, cholestyramine, aethinyloestradiol) changes in lipid metabolism. Comparison of enzyme activity in three models of changed lipoprotein metabolism has revealed that the only model used (with aethinyloestradiol) leads to the uniform changes (decrease) in LPA and LCAT. Clofibrat increased LPL activity, with LCAT activity remaining unaffected. Cholestyramine caused no changes in LPL activity, but increased LCAT activity. The results obtained suggest that synergism in LPL and LCAT activity changes is registered only when lipolysis of triglyceride-saturated lipoproteins leads to the increase in the number of particles, similar in their structure and properties to high density lipoproteins, the basic LCAT structure.
在药物诱导（氯贝丁酯、消胆胺、乙炔雌二醇）导致脂质代谢变化的情况下，对大鼠的脂蛋白脂肪酶（LPL）和卵磷脂胆固醇酰基转移酶（LCAT）活性进行了研究。对三种脂蛋白代谢改变模型中的酶活性进行比较后发现，所使用的唯一模型（乙炔雌二醇模型）会导致LPA和LCAT发生一致的变化（降低）。氯贝丁酯增加了LPL活性，而LCAT活性未受影响。消胆胺对LPL活性没有影响，但增加了LCAT活性。所得结果表明，只有当甘油三酯饱和脂蛋白的脂解导致颗粒数量增加，且这些颗粒在结构和性质上与高密度脂蛋白（基本LCAT结构）相似时，才会出现LPL和LCAT活性变化的协同作用。
