Dermatology Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt; and.
Faculty of Medicine, Newgiza University, Giza, Egypt.
Am J Dermatopathol. 2024 Apr 1;46(4):228-231. doi: 10.1097/DAD.0000000000002642. Epub 2024 Mar 8.
Epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is an unusual vascular proliferation that tends to manifest in the head and neck region. Its occurrence on the penis is rare, with only scarce reported cases in the literature. The histopathological examination of this condition poses a challenge because it shares similarities with other entities, such as epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule, or Kaposi sarcoma (KS). The infrequency of EH in penile locations underscores the need for accurate diagnostic differentiation and tailored treatment strategies for this atypical presentation. This case report highlights a rare instance of multifocal penile EH. The patient's lesions exhibited distinctive histopathologic features, with extensive eosinophilic infiltration, presence of necrosis, and infiltration to subcutaneous fat. The patient was treated with doxorubicin, a chemotherapy drug, with a very good response. This successful therapeutic outcome underscores the potential efficacy of doxorubicin in the management of multifocal penile EH. The comprehensive analysis of this case contributes to our understanding of the clinical presentation, histopathologic features, and treatment modalities for this rare penile tumor, providing valuable insights for future clinical considerations.
上皮样血管内皮细胞瘤（EH），又称伴嗜酸性粒细胞增多的血管淋巴样增生，是一种不常见的血管增生性病变，倾向于发生在头颈部。其在阴茎上的发生较为罕见，文献中仅有少数报道病例。由于该病变在组织病理学检查上具有与其他病变（如上皮样血管内皮细胞瘤、上皮样血管肉瘤、皮肤上皮样血管性丘疹或卡波西肉瘤）相似的特征，因此存在一定的诊断挑战。EH 在阴茎部位的罕见性强调了准确的诊断鉴别和针对这种非典型表现的个体化治疗策略的重要性。本病例报告重点介绍了一例罕见的多灶性阴茎 EH。患者的病变具有独特的组织病理学特征，广泛的嗜酸性粒细胞浸润、坏死和向皮下脂肪浸润。患者接受了多柔比星（一种化疗药物）治疗，取得了非常好的反应。这一成功的治疗结果突显了多柔比星在多灶性阴茎 EH 治疗中的潜在疗效。对该病例的综合分析有助于我们了解这种罕见阴茎肿瘤的临床表现、组织病理学特征和治疗方式，为未来的临床考虑提供了有价值的见解。
