Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India.
Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India.
Adv Colloid Interface Sci. 2024 Apr;326:103121. doi: 10.1016/j.cis.2024.103121. Epub 2024 Mar 5.
Conventional drug delivery systems are associated with various shortcomings, including low bioavailability and limited control over release. Biodegradable polymeric microparticles have emerged as versatile carriers in drug delivery systems addressing all these challenges. This comprehensive review explores the dynamic landscape of microparticles, considering the role of hydrophilic and hydrophobic materials. Within the continuously evolving domain of microparticle preparation methods, this review offers valuable insights into the latest advancements and addresses the factors influencing microencapsulation, which is pivotal for harnessing the full potential of microparticles. Exploration of the latest research in this dynamic field unlocks the possibilities of optimizing microencapsulation techniques to produce microparticles of desired characteristics and properties for different applications, which can help contribute to the ongoing evolution in the field of pharmaceutical science.
传统的药物输送系统存在着各种缺点，包括生物利用度低和对释放的控制有限。可生物降解的聚合物微球作为药物输送系统的多功能载体，解决了所有这些挑战。本综述探讨了微球的动态领域，考虑了亲水和疏水材料的作用。在微球制备方法不断发展的领域内，本综述提供了对最新进展的宝贵见解，并讨论了影响微囊化的因素，这对于充分发挥微球的潜力至关重要。探索这个充满活力的领域的最新研究成果，为优化微囊化技术以生产出具有不同应用所需特性和性能的微球开辟了可能性，这有助于推动药物科学领域的不断发展。
