Park Jae Hyung, Ye Mingli, Park Kinam
Department of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Molecules. 2005 Jan 31;10(1):146-61. doi: 10.3390/10010146.
Drug delivery has become increasingly important mainly due to the awareness of the difficulties associated with a variety of old and new drugs. Of the many polymeric drug delivery systems, biodegradable polymers have been used widely as drug delivery systems because of their biocompatibility and biodegradability. The majority of biodegradable polymers have been used in the form of microparticles, from which the incorporated drug is released to the environment in a controlled manner. The factors responsible for controlling the drug release rate are physicochemical properties of drugs, degradation rate of polymers, and the morphology and size of microparticles. This review discusses the conventional and recent technologies for microencapsulation of the drugs using biodegradable polymers. In addition, this review presents characteristics and degradation behaviors of biodegradable polymers which are currently used in drug delivery.
由于认识到各种新旧药物存在的困难，药物递送变得越来越重要。在众多聚合物药物递送系统中，可生物降解聚合物因其生物相容性和可生物降解性而被广泛用作药物递送系统。大多数可生物降解聚合物以微粒形式使用，其中所含药物以可控方式释放到环境中。控制药物释放速率的因素包括药物的物理化学性质、聚合物的降解速率以及微粒的形态和大小。本文综述了使用可生物降解聚合物对药物进行微囊化的传统技术和最新技术。此外，本文还介绍了目前用于药物递送的可生物降解聚合物的特性和降解行为。
