传染病的 RNA 疗法。

RNA therapeutics for infectious diseases.

机构信息

School of Medicine and Pharmacy, The University of Danang, Danang, Vietnam.

Department of Intelligence Energy and Industry, School of Chemical Engineering and Materials Science, Chung-Ang University, Seoul, Republic of Korea.

出版信息

Prog Mol Biol Transl Sci. 2024;204:109-132. doi: 10.1016/bs.pmbts.2024.01.002. Epub 2024 Jan 29.

DOI:10.1016/bs.pmbts.2024.01.002

PMID:38458735

Abstract

Ribonucleic acids (RNAs), including the messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), play important roles in living organisms and viruses. In recent years, the RNA-based technologies including the RNAs inhibiting other RNA activities, the RNAs targeting proteins, the RNAs reprograming genetic information, and the RNAs encoding therapeutical proteins, are useful methods to apply in prophylactic and therapeutic vaccines. In this review, we summarize and highlight the current application of the RNA therapeutics, especially on mRNA vaccines which have potential for prevention and treatment against human and animal infectious diseases.

摘要

核糖核酸（RNAs），包括信使 RNA（mRNA）、转移 RNA（tRNA）和核糖体 RNA（rRNA），在生物和病毒中发挥着重要作用。近年来，基于 RNA 的技术，包括抑制其他 RNA 活性的 RNA、靶向蛋白质的 RNA、重编程遗传信息的 RNA 和编码治疗性蛋白质的 RNA，是应用于预防性和治疗性疫苗的有用方法。在这篇综述中，我们总结和强调了 RNA 治疗学的当前应用，特别是在 mRNA 疫苗方面，它们具有预防和治疗人类和动物传染病的潜力。