Cancer Institute, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Gastroenterology, The Affiliated Suqian First People's Hospital of Xuzhou Medical University, Suqian, Jiangsu, China.
Cell Biochem Funct. 2024 Mar;42(2):e3969. doi: 10.1002/cbf.3969.
The research of liver metastasis is a developing field. The ability of tumor cells to invade the liver depends on the complicated interactions between metastatic cells and local subpopulations in the liver (including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells, and immune-related cells). These interactions are mainly mediated by intercellular adhesion and the release of cytokines. Cell populations in the liver microenvironment can play a dual role in the progression of liver metastasis through different mechanisms. At the same time, we can see the participation of liver parenchymal cells and nonparenchymal cells in the process of liver metastasis of different tumors. Therefore, the purpose of this article is to summarize the relationship between cellular components of liver microenvironment and metastasis and emphasize the importance of different cells in the occurrence or potential regression of liver metastasis.
肝转移的研究是一个不断发展的领域。肿瘤细胞侵袭肝脏的能力取决于转移细胞与肝脏局部亚群（包括枯否细胞、肝星状细胞、肝窦内皮细胞和免疫相关细胞）之间复杂的相互作用。这些相互作用主要通过细胞间黏附和细胞因子的释放来介导。肝微环境中的细胞群可以通过不同的机制在肝转移的进展中发挥双重作用。同时，我们可以看到肝实质细胞和非实质细胞在不同肿瘤肝转移过程中的参与。因此，本文的目的是总结肝微环境细胞成分与转移的关系，并强调不同细胞在肝转移发生或潜在消退中的重要性。
