Department of Neurology, Odense University Hospital, Denmark.
Clinic on Gambling- and Binge Eating Disorder, Department of Occupational and Environmental Medicine, Odense University Hospital, Denmark.
Cephalalgia. 2024 Mar;44(3):3331024241237237. doi: 10.1177/03331024241237237.
Idiopathic intracranial hypertension (IIH) occurs more frequently in obese females of childbearing age. A link between eating disorders and poor outcome has been suggested but remains unproven.
This prospective field study at two tertiary headache centers included patients with clinically suspected IIH after standardized diagnostic work-up. Eating disorders were evaluated using validated questionnaires (EDQs). Primary outcome was the impact of eating disorders on IIH severity and outcome, secondary outcome was the prevalence and type of eating disorders in IIH compared to controls.
We screened 326 patients; 143 patients replied to the EDQs and were classified as 'IIH' or 'non-IIH' patients. The demographic profile of EDQ-respondents and non-respondents was similar. Presence of an eating disorder did not impact IIH severity (lumbar puncture opening pressure (p = 0.63), perimetric mean deviation (p = 0.18), papilledema (Frisén grad 1-3; p = 0.53)) nor IIH outcome (optic nerve atrophy (p = 0.6), impaired visual fields (p = 0.18)). Moreover, we found no differences in the prevalence and type of eating disorders when comparing IIH with non-IIH patients (p = 0.09).
Eating disorders did not affect IIH severity or outcome. We found the same prevalence and distribution pattern of eating disorders in IIH and non-IIH patients advocating against a direct link between IIH and eating disorders.
特发性颅内高压（IIH）在肥胖的育龄期女性中更为常见。已有研究提示进食障碍与不良预后之间存在关联，但尚未得到证实。
本前瞻性现场研究在两家三级头痛中心进行，纳入经标准化诊断后疑似 IIH 的患者。采用经过验证的问卷（EDQ）评估进食障碍。主要结局为进食障碍对 IIH 严重程度和结局的影响，次要结局为 IIH 患者中进食障碍的患病率和类型与对照组的比较。
我们筛查了 326 例患者；143 例患者回复了 EDQ，并被分类为“IIH”或“非-IIH”患者。EDQ 应答者和未应答者的人口统计学特征相似。进食障碍的存在并不影响 IIH 的严重程度（腰椎穿刺开放压（p=0.63）、周边平均偏差（p=0.18）、视乳头水肿（Frisén 分级 1-3；p=0.53））或 IIH 结局（视神经萎缩（p=0.6）、视野受损（p=0.18））。此外，当比较 IIH 与非-IIH 患者时，我们发现进食障碍的患病率和类型无差异（p=0.09）。
进食障碍并未影响 IIH 的严重程度或结局。我们发现 IIH 患者和非 IIH 患者的进食障碍患病率和分布模式相同，这表明 IIH 与进食障碍之间不存在直接联系。
